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- W2384405812 abstract "Objective To explore gene mutations and mRNA expression of PTEN in cases of hepatocellular carcinoma(HCC) exvposed to both hepatitis B virus and aflatoxin B1(HBV/AFB1).Methods A total of 108 cases of HCC from different districts of Guangxi were divided into 4 groups according to their exposure to HBV and AFB1:group A,HBV(+)/AFB1-DNA(+),48 cases;group B,HBV(+)/AFB1-DNA(-),27 cases;group C,HBV(-)/AFB1-DNA(+),19 cases;and group D,HBV(-)/AFB1-DNA(-),14 cases.PTEN mutations in exons 4,5,and 8 were detected by PCR and direct sequencing,and mRNA expression was analyzed by RT-PCR.Results PTEN mutations in exons 4,5,or 8 were not found in any of the cases.However,a large deletion at the junction of exon 4 and intron 4 was found in 61 cases,corresponding to a deletion rate of 56.4%.The rate of PTEN deletion was 60.4% in group A,62.9% in group B,47.3% in group C and 46.6% in group D.The deletion rate was not statistically significant among the four sub-groups.Semi-quantitative gray values of the PTEN mRNA expression assay were as follows:group A,0.54 ± 0.13;group B,0.59± 0.16;group C,0.97 ± 0.16;group D,0.92 ± 0.13.The pair of groups A/B and the pair C/D differed significantly from each another in PTEN mRNA expression(PAC=0.002,PAD=0.032,PBC=0.000,PBD=0.011).Conclusions Down-regulation of PTEN mRNA expression is a frequent molecular event in HCC involving double exposure to HBV/AFB1 in Guangxi,and it may be related to HBV infection.AFB1 and HBV may act synergistically to down-regulate PTEN mRNA levels." @default.
- W2384405812 created "2016-06-24" @default.
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- W2384405812 date "2012-01-01" @default.
- W2384405812 modified "2023-09-26" @default.
- W2384405812 title "PTEN genetic mutations and mRNA expression in cases of human hepatocellular carcinoma exposed to hepatatitis B virus and aflatoxin B_1 in Guangxi" @default.
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