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- W2384406384 abstract "Objective:To clone ATRA regulated gene in esophageal squamous cancer cell line EC8712 Methods:By using AP PCR technique, differentially expressed gene fragments (ESTs) were isolated from ATRA treated EC8712 Cloning, sequencing and homology analysis were carried out to characterize an isolated differentitally expressed gene fragment Results:The differentially expressed gene fragment was isolated, cloned and sequenced, the gene expression was inhibited during whole ATRA treatment period, from first day to 9th day Homology analysis revealed that the fragment derives from human N ethylmalimide sensitive factor (NSF) gene, which is involed in vesicle transportation, expresses in various tissues, and plays important roles in differentiation of cells Conclusion:The decrease in activity of cellular vesicle transportation plays important roles in cellular differentiation process Down regulation of NSF might contribute to decreased activity of vesicle transportation and differentiation of human cancer cell" @default.
- W2384406384 created "2016-06-24" @default.
- W2384406384 creator A5026682959 @default.
- W2384406384 date "2000-01-01" @default.
- W2384406384 modified "2023-09-26" @default.
- W2384406384 title "Esophageal squamous carcinoma cell differentiation-related gene N-ethylmalimide sensitive factor (NSF)" @default.
- W2384406384 hasPublicationYear "2000" @default.
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