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- W2384419982 abstract "Objective To observe the expression of metalloproteinases-9(MMP-9)and tissue inhibitors of metalloproteinases-1(TIMP-1)in myocardium of diabetic rat dynamically,and the therapeutic effect of all-trans retinoic acid(ATRA).Methods Diabetic rat models were induced with streptozotocin(STZ,60 mg/kg body weight intravenously)and divided into DM 30 d,DM 60 d,DM+ATRA 30 d and DM+ATRA 60 d groups randomly.There were normal rats as control group.The ratio of heart mass and body mass of rats were measured,and the myocardium histomorphology with Haematoxylin and Eosin(HE)staining were observed.And the expressions of MMP-9 and TIMP-1 were estimated with immunohistochemical technique.Results The level of heart mass and body mass were lower in DM group than normal control group,otherwise the ratio of heart mass and body mass was increased(P0.05).The fasting blood glucose was significant increased in the diabetic rat(P0.05)and there was no statistical significant between ATRA treatment group and DM group.It demonstrated that the expression of MMP-9 and TIMP-1 in diabetic rats was higher than the same period control group(P0.05),and DM+ATRA group was lower than DM group(P0.05).The myocardium histomorphology was significantly changed in the DM group,although ATRA treatment lessen the change.Conclusion The unbalance of the expression of MMP-9 and TIMP-1 may induce myocardium hypertrophy and chance of histomorphology in diabetic rats,the ATRA could be used to improve the myocardium reconstruction through recovery the unbalance." @default.
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- W2384419982 date "2008-01-01" @default.
- W2384419982 modified "2023-09-26" @default.
- W2384419982 title "Expression of MMP-9 and TIMP-1 in myocardium of the diabetic rats and the therapeutic effects of all-trans retinoic acid" @default.
- W2384419982 hasPublicationYear "2008" @default.
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