Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384426511> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2384426511 abstract "Summary An abnormality in platelet aggregability or fibrinolysis, namely elevated activity of plasminogen activator inhibitor-1 (PAI-1), has been recently documented in patients suffering from Klinefelter’s syndrome associated with leg ulceration without underlying venous insufficiency. To determine whether increased PAI-1 activity is a general feature of Klinefelter’s syndrome, or more specifically associated with leg ulceration, we investigated PAI-1 influencing parameters and PAI-1 activity in two groups of patients: (i) Klinefelter patients suffering from leg ulceration (n o 7); and (ii) Klinefelter patients without leg ulceration (n o 6). On analysing PAI-1 influencing parameters such as age, body mass index, triglycerides, C-reactive protein, testosterone, smoking behaviour, the presence of diabetes mellitus, and arterial hypertension, respectively, we found no statistically significant differences between the two groups. However, PAI-1 activity in group 1 was highly significantly elevated compared with that in group two patients (P < 0 : 005). We conclude that (i) PAI-1 activity is not elevated in Klinefelter’s syndrome in general; (ii) elevation of PAI-1 activity in patients suffering from Klinefelter’s syndrome does not appear to be secondary to PAI-1 influencing parameters; and (iii) elevation of PAI-1 activity may play a crucial role in the pathogenesis of leg ulceration in Klinefelter’s syndrome. Therefore, a therapy for leg ulceration in Klinefelter’s syndrome that aims to return the elevated PAI-1 activity to normal should be explored." @default.
- W2384426511 created "2016-06-24" @default.
- W2384426511 creator A5004116023 @default.
- W2384426511 date "1997-01-01" @default.
- W2384426511 modified "2023-09-24" @default.
- W2384426511 title "Leg ulcers in Klinefelter's syndrome - further evidence for an involvement of plasminogen activator inhibitor-1" @default.
- W2384426511 cites W100547772 @default.
- W2384426511 cites W12830774 @default.
- W2384426511 cites W156309533 @default.
- W2384426511 cites W1979402100 @default.
- W2384426511 cites W1984890126 @default.
- W2384426511 cites W1984973445 @default.
- W2384426511 cites W1989142015 @default.
- W2384426511 cites W2005809346 @default.
- W2384426511 cites W2013077332 @default.
- W2384426511 cites W2044058620 @default.
- W2384426511 cites W2045516544 @default.
- W2384426511 cites W2047267350 @default.
- W2384426511 cites W2059983604 @default.
- W2384426511 cites W2069448284 @default.
- W2384426511 cites W2073617254 @default.
- W2384426511 cites W2078892391 @default.
- W2384426511 cites W2080545008 @default.
- W2384426511 cites W2085176649 @default.
- W2384426511 cites W2098091760 @default.
- W2384426511 cites W2413245510 @default.
- W2384426511 cites W2418407347 @default.
- W2384426511 cites W2438968104 @default.
- W2384426511 cites W2474166650 @default.
- W2384426511 hasPublicationYear "1997" @default.
- W2384426511 type Work @default.
- W2384426511 sameAs 2384426511 @default.
- W2384426511 citedByCount "0" @default.
- W2384426511 crossrefType "journal-article" @default.
- W2384426511 hasAuthorship W2384426511A5004116023 @default.
- W2384426511 hasConcept C118552586 @default.
- W2384426511 hasConcept C126322002 @default.
- W2384426511 hasConcept C134018914 @default.
- W2384426511 hasConcept C2776314099 @default.
- W2384426511 hasConcept C2776825266 @default.
- W2384426511 hasConcept C2779679481 @default.
- W2384426511 hasConcept C2780675426 @default.
- W2384426511 hasConcept C50965678 @default.
- W2384426511 hasConcept C71924100 @default.
- W2384426511 hasConcept C90924648 @default.
- W2384426511 hasConceptScore W2384426511C118552586 @default.
- W2384426511 hasConceptScore W2384426511C126322002 @default.
- W2384426511 hasConceptScore W2384426511C134018914 @default.
- W2384426511 hasConceptScore W2384426511C2776314099 @default.
- W2384426511 hasConceptScore W2384426511C2776825266 @default.
- W2384426511 hasConceptScore W2384426511C2779679481 @default.
- W2384426511 hasConceptScore W2384426511C2780675426 @default.
- W2384426511 hasConceptScore W2384426511C50965678 @default.
- W2384426511 hasConceptScore W2384426511C71924100 @default.
- W2384426511 hasConceptScore W2384426511C90924648 @default.
- W2384426511 hasLocation W23844265111 @default.
- W2384426511 hasOpenAccess W2384426511 @default.
- W2384426511 hasPrimaryLocation W23844265111 @default.
- W2384426511 hasRelatedWork W1494967191 @default.
- W2384426511 hasRelatedWork W1995916011 @default.
- W2384426511 hasRelatedWork W2001544711 @default.
- W2384426511 hasRelatedWork W2008768924 @default.
- W2384426511 hasRelatedWork W2053388994 @default.
- W2384426511 hasRelatedWork W2059571870 @default.
- W2384426511 hasRelatedWork W2092362047 @default.
- W2384426511 hasRelatedWork W2122485220 @default.
- W2384426511 hasRelatedWork W2132948268 @default.
- W2384426511 hasRelatedWork W2170112106 @default.
- W2384426511 hasRelatedWork W2376397027 @default.
- W2384426511 hasRelatedWork W2390504949 @default.
- W2384426511 hasRelatedWork W2392459816 @default.
- W2384426511 hasRelatedWork W248942659 @default.
- W2384426511 hasRelatedWork W2603815916 @default.
- W2384426511 hasRelatedWork W2963277431 @default.
- W2384426511 hasRelatedWork W3018241306 @default.
- W2384426511 hasRelatedWork W74659383 @default.
- W2384426511 hasRelatedWork W1983842894 @default.
- W2384426511 hasRelatedWork W2576702626 @default.
- W2384426511 isParatext "false" @default.
- W2384426511 isRetracted "false" @default.
- W2384426511 magId "2384426511" @default.
- W2384426511 workType "article" @default.