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- W2384444925 abstract "Objective To explore the effect of cytotoxic drugs on neuroblastoma cell line SY5Y and the influence of γ-interferon(IFN-γ)on the antitumor effects of cytotoxic drugs.Methods The expression of cysteine containing asparate specific protease 8(Caspase 8)mRNA was detected with reverse transcriptase-polymerase chain reaction(RT-PCR).The effects of cytotoxic drugs [adriamycin,tumor necrosis factor(TNF-α)and tumor necrosis factor related apoptosis inducing ligand(TRAIL)] and IFN-γ combined with cytotoxic drugs on the apoptosis of SY5Y cells were detected with flow cytometry.The relative Caspase 8 activity was measured by colorimetric assay.Results Caspase 8 was undetectable in SY5Y cells with an increased expression of Caspase 8 after treated with IFN-γ.SY5Y cells were sensitive to adriamycin relatively but resistant to TNF-α and TRAIL,while IFN-γ-pretreated SY5Y cells were more sensitive to the cytotoxic drugs with an increase of Caspase 8 activity but the killing effects could be blocked by Caspase 8 inhibitor.Conclusion IFN-γ can sensitize SY5Y cells to cytotoxic drugs-induced apoptosis and this may be realized by the up-regulation of Caspase 8." @default.
- W2384444925 created "2016-06-24" @default.
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- W2384444925 date "2009-01-01" @default.
- W2384444925 modified "2023-09-26" @default.
- W2384444925 title "Effect of cytotoxic drugs on the induced-apoptosis of neuroblastoma cells enhanced by IFN-γ" @default.
- W2384444925 hasPublicationYear "2009" @default.
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