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- W2384449166 abstract "【Objective】 To investigate the relationship between polymorphisms of the VDR gene and the NRAMP1 gene and the susceptibility of PTB in Chinese Uighurs.【Methods】 Using case-control study,Genotyping of the 3'-UTR of NRAMP1 gene,FokI and TaqI of VDR gene was done by PCR-RFLP among 224 patients and 225 healthy contacts.Chi-square test was used to analyze the association between the three sites and tuberculosis.【Results】 In the tuberculosis patients,genotype TGTG/TGTG,TGTG/del,and TGTGdel/del were observed in 159,56 and 9 cases respectively,while the genotypes of the healthy controls were TGTG/TGTG in 185,TGTG/del in 36 and TGTGdel/del in 4 case.TGTG/del genotype had significant increased risk of tuberculosis(OR=1.810),the allele frequencies of TGTGdel were statistic significances in tuberculosis group compared with control group(P 0.01).The genotype FF,Ff,ff were observed in 81,127 and 16 cases among tuberculosis group while in 91,120 and 14 cases among control group.The frequencies of VDR-FokI FF,Ff and ff genotypes had no statistically significant difference between the case and the control group.The allele frequencies of F and f were not statistic significances in tuberculosis group compared with control group(P 0.05).The genotype of TT were in 154 cases,Tt in 66 cases and tt in 4 cases among patients while TT in 170 cases,Tt in 50 cases and tt in 5 cases among controls.The frequencies of VDR-TaqI tt,Tt,TT genotypes had no statistically significant difference between the case and the control group.The allele frequencies of T and t were not statistic significances in tuberculosis group compared with control group(P 0.05).D′=0.017,r 2=0.00,The two polymorphisms of VDR didn't show linkage disequilibrium.【Conclusion】 The Uighurs in Xinjiang carrying TGTG/del genotype was apt to suffer tuberculosis;The TGTG del allele may be a risk factor for the tuberculosis of Xinjiang Uighurs.No evidence supported that the FokI and TaqI polymorphisms were associated with TB in Uighurs of Xinjiang.The two polymorphisms didn't show linkage disequilibrium." @default.
- W2384449166 created "2016-06-24" @default.
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- W2384449166 date "2011-01-01" @default.
- W2384449166 modified "2023-09-23" @default.
- W2384449166 title "Study on susceptibility genes polymorphisim to tuberculosis in Uighurs of Xinjiang" @default.
- W2384449166 hasPublicationYear "2011" @default.
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