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- W2384453307 abstract "Objective Paraquat( PQ) is an effective herbicide which is widely used in agricultural production. PQ poisoning is frequently seen in humans with the lung as the target organ,but the poisoning mechanisms is not very clear. Studies show that endoplasmic reticulum stress( ERS) is closely associated with poisoning,but there are few reports on the relationship between ER stress and PQ poisoning. This article was to investigate the effects of ERS-induced apoptosis and total flavonoids from astragalus complanatus( FAC) in acute lung injury( ALI) following paraquat poisoning in rats. Methods A total of 30 adult healthy Sprague-Dawley( SD) rats were randomly divided into 3 groups: control group,ALI group,ALI + FAC group and ALI + saline group. Biochemical method was applied to detect superoxide dismutase( SOD),catalase( CAT) and malondialdehyde( MDA) in lung tisssue,TdT-mediated dUTP nick end labeling( TUNEL) assay in observing lung apoptosis,Western blotting and real-time PCR( RT-PCR) in detecting the changes in expressions of C /EBP homologous peotein( CHOP),activating transcription factor 4( ATF4) and X-box binding protein 1( XBP) following ALI,and HE staining in observing the pathological changes of lung tissue. Results Compared with control group,the expression of MDA content was enhanced in ALI group( [3. 26 ± 0. 24]vs [5. 04 ± 0. 36],P 0. 01),along with significantly decreased activity of SOD and CAT( [300.26 ±35.69]vs[187.21 ±25.66]),( [5.78 ±1.28]vs[2.15 ±1.12],P 0.01),increased cell apoptosis,upregulated protain level of CHOP( [0. 74 ± 0. 20]vs [0. 23 ± 0. 07],P 0. 01) and mRNA expression of ATF4,XBP1 and CHOP. However,FAC significantly attenuated ALI following PQ,as showed by reduced MDA content,enhanced activity of SOD and CAT,decreased cell apoptosis,inhibited protain level of CHOP and mRNA expression of ATF4,XBP1 and CHOP( [5. 04 ± 0. 36]vs [3. 99 ± 0. 27],P 0. 01).Furthermore,the activity of SOD and CAT were higher in FAC pretreatment group than those in ALI group( [0. 74 ± 0. 20] vs[0.42 ±0.11],P 0.01). Conclusion From the research,ERSinduced cell apoptosis is involved in ALI following PQ,and the protective role of FAC in lung tissue following PQ is due to its effect in attenuating ERS-induced apoptosis." @default.
- W2384453307 created "2016-06-24" @default.
- W2384453307 creator A5079408077 @default.
- W2384453307 date "2014-01-01" @default.
- W2384453307 modified "2023-09-25" @default.
- W2384453307 title "Effects of total flavonoids from astragalus complanatus and endoplasmic reticulum stress-induced cell apoptosis in acute lung injury following paraquat poisoning in rats" @default.
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