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- W2384454316 abstract "Objective To investigate the possible mechanism of valproic acid(VPA)-induced apoptosis of K562 cells.Methods The K562 cells were divided into two groups of A(treated with 2.0 mmol/L VPA) and B(normal control group),which were respectively cultured for 24,48 and 72 h.The ratio of cell apoptosis and the changes of mitochondrial membrane potential were detected by flow cytometry.The protein activities of cystein asparate proteinase(Caspase)-8 and Caspase-9 were detected by spectrophotometry.Results The ratio of cell apoptosis and destruction rate of mitochondrial membrane potential wereincreased in a time-dependent manner in group A,which were obviously higher than those in group B(P0.05).Compared with group B,the activities of Caspase-8 and Caspase-9 in group A were up-regulated during different culture times(P0.05).ConclusionThe potential mechanism of K562 cell apoptosis induced by VPA might be related to the collapse of mitochondrial membrane potential and the death receptor pathway." @default.
- W2384454316 created "2016-06-24" @default.
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- W2384454316 date "2011-01-01" @default.
- W2384454316 modified "2023-09-26" @default.
- W2384454316 title "Investigation of mechanism for valproic acid-induced apoptosis of K562 cells" @default.
- W2384454316 hasPublicationYear "2011" @default.
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