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- W2384455246 abstract "Objective To explore the influence and the possible mechanism of programmed cell death-1(PDL1) on the cut-tail survival after rat tail replantation. Methods Rat tail replantation model was made, 40 successful rat tail replantation models were randomly selected,and divided into two groups:group PD-L1(infiltratively injecting recombinant rat PD-L1 protein in the ring operation incision)and saline group(infiltratively injecting normal saline in the ring operation incision),another 10 rats were used as control. The serum level of PD-L1 was detected with ELISA method. After applying of recombinant rat PD-L1, the vascular crisis was evaluated in the rat tail replantation model. Vascular endothelial growth factor(VEGF) and CD34 expression levels in the cut-tail were detected by Western blot. Results Compared with preoperative rats, PD-L1 levels of postoperation rats at different time points were increased significantly, and reached the peak at 48 h after operation, then down to nomal level at 7d after operation. After applying of recombinant rat PD-L1, the blood circulation of cut-tail improved and vascular crisis rate was significant lower. Compared with normal rats, levels of VEGF and CD34 increased in cut-tail of model rats(P0.05). The recombinant PD-L1 upregulated the levels of VEGF and CD34 at 48 h postoperation. Conclusion The promotion of cut-tail replantation survival by PD-L1 might be related to the upregulation of VEGF and CD34 expression." @default.
- W2384455246 created "2016-06-24" @default.
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- W2384455246 date "2015-01-01" @default.
- W2384455246 modified "2023-09-23" @default.
- W2384455246 title "The possible mechanism of PD-L1 promoting survival in rat tail replantation" @default.
- W2384455246 hasPublicationYear "2015" @default.
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