Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384455437> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2384455437 abstract "Objective To explore the therapeutic potential of striatal-derived neurotrophic factor (SDNF) in Parkinson′s disease. Method The 6-hydroxydopamine (6-OHDA) induced hemiparkinsonian rat model was established and the intranigral single injection of SDNF at early stage of 6-OHDA lesion and the supernigral repeated injection of SDNF 2 weeks later in 6-OHDA lesion were performed to observe the therapeutic role of SDNF on the rat model. Results The early single injection of SDNF could arrest a decline of the number of mesencephalic dopamine (DA) neurons caused by 6-OHDA lesion.Although there was no obvious influence on the survival number of mesencephalic DA neurons in the repeated injection of SDNF 2 weeks later in 6-OHDA lesion,it could decrease the average rate of apomorphine-induced rotations of rat model and increase the level of DA as well as reduce the rate of homovanillic acid (HVA) level to DA level in the lesion side of striatum of rat model. Conclusion SDNF may prevent the degeneration of mesencephalic DA neurons at early stage of 6-OHDA lesion and enhance the function of remaining DA neurons later." @default.
- W2384455437 created "2016-06-24" @default.
- W2384455437 creator A5048869783 @default.
- W2384455437 date "2000-01-01" @default.
- W2384455437 modified "2023-09-23" @default.
- W2384455437 title "An Experimental Study of Striatal-derived Neurotrophic Factor Treating the Rat Model of Parkinson′s Disease" @default.
- W2384455437 hasPublicationYear "2000" @default.
- W2384455437 type Work @default.
- W2384455437 sameAs 2384455437 @default.
- W2384455437 citedByCount "0" @default.
- W2384455437 crossrefType "journal-article" @default.
- W2384455437 hasAuthorship W2384455437A5048869783 @default.
- W2384455437 hasConcept C126322002 @default.
- W2384455437 hasConcept C134018914 @default.
- W2384455437 hasConcept C137183658 @default.
- W2384455437 hasConcept C142724271 @default.
- W2384455437 hasConcept C15744967 @default.
- W2384455437 hasConcept C160539049 @default.
- W2384455437 hasConcept C169760540 @default.
- W2384455437 hasConcept C170493617 @default.
- W2384455437 hasConcept C2775841634 @default.
- W2384455437 hasConcept C2775864247 @default.
- W2384455437 hasConcept C2777288102 @default.
- W2384455437 hasConcept C2777525119 @default.
- W2384455437 hasConcept C2779134260 @default.
- W2384455437 hasConcept C2779734285 @default.
- W2384455437 hasConcept C2780062018 @default.
- W2384455437 hasConcept C2780938664 @default.
- W2384455437 hasConcept C2781156865 @default.
- W2384455437 hasConcept C513476851 @default.
- W2384455437 hasConcept C71924100 @default.
- W2384455437 hasConcept C92020748 @default.
- W2384455437 hasConceptScore W2384455437C126322002 @default.
- W2384455437 hasConceptScore W2384455437C134018914 @default.
- W2384455437 hasConceptScore W2384455437C137183658 @default.
- W2384455437 hasConceptScore W2384455437C142724271 @default.
- W2384455437 hasConceptScore W2384455437C15744967 @default.
- W2384455437 hasConceptScore W2384455437C160539049 @default.
- W2384455437 hasConceptScore W2384455437C169760540 @default.
- W2384455437 hasConceptScore W2384455437C170493617 @default.
- W2384455437 hasConceptScore W2384455437C2775841634 @default.
- W2384455437 hasConceptScore W2384455437C2775864247 @default.
- W2384455437 hasConceptScore W2384455437C2777288102 @default.
- W2384455437 hasConceptScore W2384455437C2777525119 @default.
- W2384455437 hasConceptScore W2384455437C2779134260 @default.
- W2384455437 hasConceptScore W2384455437C2779734285 @default.
- W2384455437 hasConceptScore W2384455437C2780062018 @default.
- W2384455437 hasConceptScore W2384455437C2780938664 @default.
- W2384455437 hasConceptScore W2384455437C2781156865 @default.
- W2384455437 hasConceptScore W2384455437C513476851 @default.
- W2384455437 hasConceptScore W2384455437C71924100 @default.
- W2384455437 hasConceptScore W2384455437C92020748 @default.
- W2384455437 hasLocation W23844554371 @default.
- W2384455437 hasOpenAccess W2384455437 @default.
- W2384455437 hasPrimaryLocation W23844554371 @default.
- W2384455437 hasRelatedWork W1900535849 @default.
- W2384455437 hasRelatedWork W202064371 @default.
- W2384455437 hasRelatedWork W2029945109 @default.
- W2384455437 hasRelatedWork W2040934666 @default.
- W2384455437 hasRelatedWork W2041485233 @default.
- W2384455437 hasRelatedWork W2041709722 @default.
- W2384455437 hasRelatedWork W2049791800 @default.
- W2384455437 hasRelatedWork W2071277983 @default.
- W2384455437 hasRelatedWork W2077898869 @default.
- W2384455437 hasRelatedWork W2129479963 @default.
- W2384455437 hasRelatedWork W2170284001 @default.
- W2384455437 hasRelatedWork W2309837904 @default.
- W2384455437 hasRelatedWork W2341572941 @default.
- W2384455437 hasRelatedWork W2385027040 @default.
- W2384455437 hasRelatedWork W2469994264 @default.
- W2384455437 hasRelatedWork W2799352425 @default.
- W2384455437 hasRelatedWork W3088500573 @default.
- W2384455437 hasRelatedWork W3089068851 @default.
- W2384455437 hasRelatedWork W3198139360 @default.
- W2384455437 hasRelatedWork W2184428384 @default.
- W2384455437 isParatext "false" @default.
- W2384455437 isRetracted "false" @default.
- W2384455437 magId "2384455437" @default.
- W2384455437 workType "article" @default.