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- W2384457573 abstract "Objective To investigate the effects of antioxidant Chuanxiongzine and Na+/H+ exchanger inhibitor Amiloride on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro. Methods HSC-T6 were incubated with different concentrations of Chuanxiongzine and Amiloride for 24 h. MTT colorimetry was used for assaying proliferation of HSC. Cytotoxicity was measured by LDH colorimetry. Type Ⅰcollage was determined by ELISA. Hyaluronic Acid and Laminin were measured by Radioimmunoassay. Results 1~20 mol/L Chuanxiongzine and Amiloride added in culture medium had no cytotoxicity to HSC, but could significantly inhibite HSC proliferation, and also inhibite the secretion of Type Ⅰ collage. Combining Chuanxiongzine with amiloride had better effects on proliferation and extracellular matrix secretion of rat hepatic stellate cells than single Chuanxiongzine or amiloride alone. Conclusion The effects of combination of antifibrosis drugs on different targets of HSC are superior to those of each one." @default.
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- W2384457573 date "2008-01-01" @default.
- W2384457573 modified "2023-09-26" @default.
- W2384457573 title "Effects of Chuanxiongzine and Amiloride on Proliferation and Extracellular Matrix Secretion of Rat Hepatic Stellate Cells in vitro" @default.
- W2384457573 hasPublicationYear "2008" @default.
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