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- W2384464241 abstract "Objective To observe the effect of TCM compound prescription,Tangbikang on blood relevant factors in rats with diabetic peripheral neuropathy(DPN).Methods The DPN model rats were established by streptozotocin and randomly divided into a model group,a mecobalamin group and a low-,medium-and high-dose of Tangbikang prescription(LT,MT and HT) group.The changes of blood sugar,blood lipid,whole blood viscosity,thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α),nitric oxide(NO) and endothelin(ET) in rats of all groups were observed after 12-week intervention treatment.Results After 12-week administration,the low-shear blood viscosity in the MT group was obviously decreased,which had significant difference compared with the model group(P 0.05);while the whole blood viscosity in the other treated groups showed an apparent descending trend with insignificant differences(P 0.05).The high-density lipoprotein level in the LT and MT group was increased significantly compared with that in the model group(P 0.01),and the level of total cholesterol was decreased significantly(P 0.05);the low-density lipoprotein level in the MT and HT group was decreased significantly(P 0.01).Compared with the model group,the contents of NO in the MT and HT group were increased apparently,while the contents of ET and TXB2 were decreased apparently(P 0.01 or P 0.05);the ratio of TXB2/6-keto-PGF1α in the MT group was decreased apparently with significant difference(P 0.01).Conclusion The Tangbikang prescription play a role in protecting peripheral nerve through decreasing the blood viscosity,blood lipid,ET content,TXB2 and ratio of TXB2/6-keto-PGF1α and increasing the NO content." @default.
- W2384464241 created "2016-06-24" @default.
- W2384464241 creator A5049328032 @default.
- W2384464241 date "2013-01-01" @default.
- W2384464241 modified "2023-09-25" @default.
- W2384464241 title "Evaluation on intervention effect of Tangbikang prescription on diabetic peripheral neuropathy from blood relevant factors" @default.
- W2384464241 hasPublicationYear "2013" @default.
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