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- W2384490815 abstract "Objective To observe the relations of soluble intercellular adhesion molecules-1(sICAM-1),vascular cell adhesion molecules-1(sVCAM-1)to blood pressure,blood sugar,blood lipid and the influence of rosuvastatin on sICAM-1 and sVCAM-1 in serum of patients with acute coronary syndrome(ACS),to probe into the mechanism of rosuvastatin lowering inflammatory reaction in ACS patients.Methods 112 elderly patients were divided into two groups:36 patients with stable angina pectoris(SAP),76 patients with ACS.The latter group were randomly divided into rosuvastatin and non-rosuvastatin sub-groups.Serum concentrations of sICAM1 and sVCAM-1 in patients with ACS were measured by ELISA at 1,3,5,7,14 day after hospitalization.Moreover,the relations of sICAM-1 and sVCAM-1 to the history of hypertension,diabetes mellitus,dyslipidemia as well as blood pressure,blood sugar,blood lipid were analyzed.Results Serum concentrations of sICAM-1 and sVCAM-1 in elderly patients with ACS were higher than those of SAP group(P0.01).sICAM-1,sVCAM-1 levels in plasma were higher in hypertension,diabetes mellitus,dyslipidemia groups than normal pressure,non-diabetes,normal lipid respectively.Mutivariable analysis showed that sICAM-1,sVCAM-1 levels in plasma were correlated to LDL-C positively(P0.01)but not heart rate,systolic pressure,diastolic pressure,TC,HDL-C,TG,FBG,HbA1C(P0.05).In two sub-groups of ACS group,serum concentrations of sICAM-1 and sVCAM-1 in rosuvastatin group were decreased more significantly than those of the other.Conclusions Endothelium impairment induced by hypertension,diabetes mellitus,dyslipidemia is important factor of elevating sICAM-1,sVCAM-1 levels in plasma;Rosuvastatin may decrease inflammatory reaction and play a pivotal role in early therapy of ACS patients." @default.
- W2384490815 created "2016-06-24" @default.
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- W2384490815 date "2011-01-01" @default.
- W2384490815 modified "2023-09-27" @default.
- W2384490815 title "The plasma levels changes and influence factors of sICAM-1,sVCAM-1 in elderly patients with acute coronary syndrome and intervention by rosuvastatin" @default.
- W2384490815 hasPublicationYear "2011" @default.
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