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- W2384495524 abstract "Objective To investigate the effect of rosuvastatin on cardio-ankle vascular index and ankle-brachial index in essential hypertensives with normal lipidemia. Methods One hundred and thirty essential hypertensives with normal lipidemia were divided into two groups: control group(n=63)and rosuvastatin group(n=67,rosuvastatin 10 mg, qn). Blood pressure of all the hypertensives were controled under 140/90 mm Hg at least four weeks through given routine antihypertensive drugs. Cardio-ankle vascular index(CAVI), ankle-brachial index(ABI), blood pressure and lipidemia were measured before and three months after treatment respectively. Results By the end of three months therapy, no significant difference in blood pressure was observed between two groups. Total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) were significantly decreased in rosuvastatin group compared with control group [(-0.10±0.06), (-0.06±0.03) mmol/L] (P0.05) and basline [(1.7±1.0), (0.7±0.4) mmol/L] (P0.05). CAVI(0.58±0.12) was significantly decreased in rosuvastatin group compared with control group (0.12±0.10) (P0.05), ABI(0.18±0.10) was significantly increased in rosuvastatin group compared with control group (-0.06±0.04) ( P0.05). There were no significant difference in the lipidemia, CAVI and ABI after three months therapy as compared with baseline (P0.05). CAVI was positively related with age, systolic pressure, TC and LDL-C; ABI was negatively related with age, systolic pressure, TC and LDL-C in Pearson and multiple stepwise regression analysis. Conclusion Rosuvastatin can exert beneficial effect on arterial function in essential hypertensives with normal lipidemia." @default.
- W2384495524 created "2016-06-24" @default.
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- W2384495524 date "2011-01-01" @default.
- W2384495524 modified "2023-09-25" @default.
- W2384495524 title "Effect of rosuvastatin on cardio-ankle vascular index and ankle-brachial index in essential hypertensives with normal lipidemia" @default.
- W2384495524 hasPublicationYear "2011" @default.
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