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- W2384501518 abstract "Objective To study the effect of bradykinin on platelet derived growth factor (PDGF) induced proliferation of cultured rat aortic vascular smooth muscle cells (VSMCs) Methods Rat aortic VSMCs were cultured.The cells after 4-6 passages were used in the experiment and divided into five groups:(1) Control; (2) PDGF(50ng/ml); (3) PDGF+Bradykinin(10 -4 mol/L); (4) PDGF+Bradykinin+Bradykinin receptor antagonist HOE 140(10 -4 mol/L); (5) PDGF+Bradykinin+Nitric Oxide synthase (NOS)inhibitor NG nitro L arginine methyl ester (L NAME)(10 -2 mol/L).Proliferation of VSMCs in culture was measured by 3H TdR incorporation into cell DNA. NO production was measured by modified Greiss method. Expression of induced NOS (iNOS) mRNA was determined by using the RT PCR technique.Results (1) Compared with control, PDGF significantly increased the 3H TdR incorporation and decreased the NO production and expression of iNOS mRNA in cultured VSMCs (p0.05). (2) The effects of PDGF were inhibited by bradykinin. However,the effect of bradykinin on PDGF could be blocked by HOE 140 and L NAME.Conclusion The results suggest that bradykinin can inhibit the proliferation of cultured VSMCs induced by PDGF, with an increase of NO production and expression of iNOS mRNA. (Shanghai Med J,2000,23:290 292)" @default.
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- W2384501518 date "1999-01-01" @default.
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- W2384501518 title "Effect of bradykinin on PDGF-induced proliferation of cultured rat aortic vascular smooth muscle cells" @default.
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