Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384523384> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2384523384 abstract "Aim To investigate the role of inhibition of the PTEN in LPS-induced acute lung injury.Methods Tirty-two male SD rats were divided into LPS group and phen + LPS group(n = 16 each),then the mortality of rats in two groups was compared.Another sixty male SD rats were divided into four groups randomly:control group(n = 6),LPS group(n = 24),phen + LPS group(n = 24),phen group(n = 6).Both LPS group and phen + LPS group were subjected to 1,3,6 h and 12 h time point subgroups after LPS administration(n = 6 each).The concentrations of protein,tumor necrosis factor-α(TNF-α) andinterleukin-6(IL-6) inbronch-oalveolar lavage fluids(BALF) were detected.The histopathologic changes of lung tissues,and the expression of p-Akt in lung tissues were also observed.Results Phen pretreatment significantly decreased the LPS-induced lethality(P 0.05).In LPS group,the protein and cytokines in BALF were significantly increased(P 0.05) and the lung tissues showed obviously inflammatory responses under light microscopy,characterized by alveolar hemorrhage,pulmonary interstitial edema,alveolar collapse and massive inflammatory cell infiltration within the lung tissues.Simultaneously,the expres-sions of p-Akt were substantially decreased immediately.Pretreatment with phen in vivo effectively attenuated the lung injury,the concentrations of protein,TNF-α and IL-6 in BALF significantly decreased(P 0.05),and the histopathologic changes of lung tissues were relieved obviously.Furthermore,the expressions of p-Akt were substantially increased(P 0.05).Conclusion Treatment with phen significantly reduces the severity of LPS-induced acute lung injury in rats." @default.
- W2384523384 created "2016-06-24" @default.
- W2384523384 creator A5020706591 @default.
- W2384523384 date "2010-01-01" @default.
- W2384523384 modified "2023-09-26" @default.
- W2384523384 title "Inhibition of the PTEN protects rats against LPS-induced acute lung injury" @default.
- W2384523384 hasPublicationYear "2010" @default.
- W2384523384 type Work @default.
- W2384523384 sameAs 2384523384 @default.
- W2384523384 citedByCount "1" @default.
- W2384523384 countsByYear W23845233842015 @default.
- W2384523384 crossrefType "journal-article" @default.
- W2384523384 hasAuthorship W2384523384A5020706591 @default.
- W2384523384 hasConcept C121332964 @default.
- W2384523384 hasConcept C126322002 @default.
- W2384523384 hasConcept C134018914 @default.
- W2384523384 hasConcept C142724271 @default.
- W2384523384 hasConcept C150903083 @default.
- W2384523384 hasConcept C153400128 @default.
- W2384523384 hasConcept C164027704 @default.
- W2384523384 hasConcept C16685009 @default.
- W2384523384 hasConcept C17991360 @default.
- W2384523384 hasConcept C185592680 @default.
- W2384523384 hasConcept C190283241 @default.
- W2384523384 hasConcept C207001950 @default.
- W2384523384 hasConcept C2776468924 @default.
- W2384523384 hasConcept C2776914184 @default.
- W2384523384 hasConcept C2777609662 @default.
- W2384523384 hasConcept C2777714996 @default.
- W2384523384 hasConcept C2778754761 @default.
- W2384523384 hasConcept C2780886150 @default.
- W2384523384 hasConcept C55493867 @default.
- W2384523384 hasConcept C71924100 @default.
- W2384523384 hasConcept C75217442 @default.
- W2384523384 hasConcept C86554907 @default.
- W2384523384 hasConcept C86803240 @default.
- W2384523384 hasConcept C97355855 @default.
- W2384523384 hasConceptScore W2384523384C121332964 @default.
- W2384523384 hasConceptScore W2384523384C126322002 @default.
- W2384523384 hasConceptScore W2384523384C134018914 @default.
- W2384523384 hasConceptScore W2384523384C142724271 @default.
- W2384523384 hasConceptScore W2384523384C150903083 @default.
- W2384523384 hasConceptScore W2384523384C153400128 @default.
- W2384523384 hasConceptScore W2384523384C164027704 @default.
- W2384523384 hasConceptScore W2384523384C16685009 @default.
- W2384523384 hasConceptScore W2384523384C17991360 @default.
- W2384523384 hasConceptScore W2384523384C185592680 @default.
- W2384523384 hasConceptScore W2384523384C190283241 @default.
- W2384523384 hasConceptScore W2384523384C207001950 @default.
- W2384523384 hasConceptScore W2384523384C2776468924 @default.
- W2384523384 hasConceptScore W2384523384C2776914184 @default.
- W2384523384 hasConceptScore W2384523384C2777609662 @default.
- W2384523384 hasConceptScore W2384523384C2777714996 @default.
- W2384523384 hasConceptScore W2384523384C2778754761 @default.
- W2384523384 hasConceptScore W2384523384C2780886150 @default.
- W2384523384 hasConceptScore W2384523384C55493867 @default.
- W2384523384 hasConceptScore W2384523384C71924100 @default.
- W2384523384 hasConceptScore W2384523384C75217442 @default.
- W2384523384 hasConceptScore W2384523384C86554907 @default.
- W2384523384 hasConceptScore W2384523384C86803240 @default.
- W2384523384 hasConceptScore W2384523384C97355855 @default.
- W2384523384 hasLocation W23845233841 @default.
- W2384523384 hasOpenAccess W2384523384 @default.
- W2384523384 hasPrimaryLocation W23845233841 @default.
- W2384523384 hasRelatedWork W2324929178 @default.
- W2384523384 hasRelatedWork W2351104916 @default.
- W2384523384 hasRelatedWork W2353162466 @default.
- W2384523384 hasRelatedWork W2354107154 @default.
- W2384523384 hasRelatedWork W2354842328 @default.
- W2384523384 hasRelatedWork W2358706576 @default.
- W2384523384 hasRelatedWork W2361191362 @default.
- W2384523384 hasRelatedWork W2361290174 @default.
- W2384523384 hasRelatedWork W2367292031 @default.
- W2384523384 hasRelatedWork W2374705608 @default.
- W2384523384 hasRelatedWork W2377073190 @default.
- W2384523384 hasRelatedWork W2384172114 @default.
- W2384523384 hasRelatedWork W2384559018 @default.
- W2384523384 hasRelatedWork W2384824719 @default.
- W2384523384 hasRelatedWork W2392380716 @default.
- W2384523384 hasRelatedWork W2573492709 @default.
- W2384523384 hasRelatedWork W2745850930 @default.
- W2384523384 hasRelatedWork W3029019419 @default.
- W2384523384 hasRelatedWork W3031802058 @default.
- W2384523384 hasRelatedWork W3032248048 @default.
- W2384523384 isParatext "false" @default.
- W2384523384 isRetracted "false" @default.
- W2384523384 magId "2384523384" @default.
- W2384523384 workType "article" @default.