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- W2384528735 abstract "Objective To find a successful therapeutic intervention for the acute lung injury induced by perfluoroisobutylene(PFIB)inhalation.Method Kunmings mice were exposed to gaseous PFIB(0 130±0 005) mg/L]for 5 minutes in a flow past whole body exposure system.Preventative effects of pyrrolidine dithiocarbamate(PDTC)the lung toxicity and the mortality of PFIB inhalation were studied.for 5 minutes in a flow past whole body exposure system.Preventative effects of pyrrolidine dithiocarbamate(PDTC)the lung toxicity and the mortality of PFIB inhalation were studied.Result PDTC(120 mg/kg)pretreatment might significantly lower the mortality when PFIB(0 170±0 005) mg/L]was inhaled for 5 min.In the mice pretreated with PDTC 30 min before PFIB exposure,could also significantly lower lung coefficient;the protein concentration in BALF in mice pretreated with PDTC 60 min,30 min or 15 min before PFIB exposure,were significantly lowered as well.These effects of PDTC were found to be dose dependent,but the acute lung injury was still aggravated when PDTC was given after the PFIB inhalation.was inhaled for 5 min.In the mice pretreated with PDTC 30 min before PFIB exposure,could also significantly lower lung coefficient;the protein concentration in BALF in mice pretreated with PDTC 60 min,30 min or 15 min before PFIB exposure,were significantly lowered as well.These effects of PDTC were found to be dose dependent,but the acute lung injury was still aggravated when PDTC was given after the PFIB inhalation.Conclusion The preventative effects of PDTC against the toxicity of PFIB inhalation were identified,but its mechanism still remains to be further clarification." @default.
- W2384528735 created "2016-06-24" @default.
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- W2384528735 date "2001-01-01" @default.
- W2384528735 modified "2023-09-25" @default.
- W2384528735 title "Effects of pyrrolidine dithiocarbamate on acute lung injury induced by perfluoroisobutylene inhalation in mice" @default.
- W2384528735 hasPublicationYear "2001" @default.
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