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- W2384538192 abstract "Objective To study the drug-resistance gene mutations in patients with mycobacterium tuberculous pleuritis and their influence on the therapeutic effect. Methods 46 patients with mycobacterium tuberculous pleuritis were given fiber bronchoscopy instead of thoracoscopy,and pleural biopsy specimens were detected by mycobacterium tuberculous gene chip. All cases were treated with chest tube drainage and anti-tuberculous therapy. Results There were 32 cases of wild-type gene and 10 cases of drug-resistance gene mutations,including 5 cases of mutations of rpoB gene against RFP,6 cases of mutations of katG gene against INH,2 cases of mutations of inhA gene against INH,1 case of mutations of embB gene against EMB,1 case of mutations of rpsL gene against SM,and6 cases of multidrug resistance gene. The duration of hospital stay was obviously longer in the group with drug-resistance gene mutations( 12. 1 ± 3. 1 d) than in the group without drug-resistance gene mutations( 8. 2 ± 2. 5 d)( P 0. 01). The chest tube drainage time was longer in the group with drug-resistance gene mutations( 7. 0 ± 2. 6 d) than in the group without drug-resistance gene mutations( 4. 0 ± 1. 8 d)( P 0. 01). The defervescence time was longer in the group with drug-resistance gene mutations( 6. 8 ± 1. 6 d) than in the group without drug-resistance gene mutations( 4. 2 ± 1. 4 d)( P 0. 01). Conclusion There are drug-resistance gene mutations in patients with mycobacterium tuberculous pleuritis and they influence the therapeutic effect significantly. Mycobacterium tuberculous gene chip technology is useful for the early detection of drug-resistance tuberculous pleuritis and may be useful for the anti-TB drug selection." @default.
- W2384538192 created "2016-06-24" @default.
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- W2384538192 date "2014-01-01" @default.
- W2384538192 modified "2023-09-27" @default.
- W2384538192 title "Application of drug-resistance mycobacterium tuberculosis gene chip in tuberculous pleuritis" @default.
- W2384538192 hasPublicationYear "2014" @default.
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