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- W2384543165 abstract "Objective To research the mechanism of High Volume Hemofiltration (HVHF) on acute lung injury (ALI) induced by LPS in dogs. Methods After injection of LPS (650 μg/kg) via central vein within 30 min, Sixteen healthy hybrid male dogs were divided into control group and treatment group randomly (n=8). PaO2、PaCO2 in artery blood were recorded. Contents of TNF-α、IL-6 and IL-10 in plasm were measured by radioimmunity. The activity of NF-кB in lung homogenate was measured by flow cytometer. The content of surfactant protein B (SP-B) in lung homogenate was measured by Western-blotting.Changes of lung histopathology was observed via electron microscopy. Results After injection of LPS, PaO2 and PaO2/FiO2 began to decrease. PaO2 and PaO2/FiO2 in treatment group kept higher than that in control group (P0.01). In treatment group, the content of TNF-α、IL-6、IL-10 in plasm obviously decreased after HVHF and the activation of NF-κB was also decreased. There was very significant difference between two groups (P0.01). The content of SP-B in lung homogenate in treatment group was significantly higher than that in control group (P0.01). Edema of alveoli and lung mesen-chymal,hemorrhage,infiltration of inflammatory cells and the injury of PC-II in treatment group were obviously lightened after HVHF. Conclusion HVHF can relieve ALI induced by LPS in dogs, which is explained by continuously elimination of inflammatory medators, the inhibition of activation of NF-κB and the down regulation of high expression of cytokines, the attenuation of mesenchymal and alveolar inflammatory edema, and the increase of content of SP-B." @default.
- W2384543165 created "2016-06-24" @default.
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- W2384543165 date "2008-01-01" @default.
- W2384543165 modified "2023-09-25" @default.
- W2384543165 title "High volume hemofiltration relieves acute lung injury induced by LPS in dogs" @default.
- W2384543165 hasPublicationYear "2008" @default.
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