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- W2384551314 abstract "Objective To evaluate the clinical value of 1H magnetic resonance spectroscopy(1H MRS)in multiple sclerosis(MS).Materials and Methods MRI and 1H MRS were performed in 21 patients with MS and healthy volunteers.NAA,Cr,Cho,and LAC peaks and the ratio of NAA/Cr,NAA/Cho and Cho/Cr were measured in the lesions,NAWM,and normal control group.Results Compared with normal control group,decreased NAA peaks and increased Cho peaks were demonstrated among lesions and NAWM in MS,and Lac peaks were also demonstrated in acute active lesions.The ratio of NAA/Cr in lesions(1.459±0.280) from MS patients was significantly decreased than that both in NAWM(1.806±0.114)and control group(2.109±0.246,F=65.159,P0.001).The ratio of NAA/Cho in lesions(0.763±0.195) was also significantly decreased than that both in NAWM(1.295±0.101) and in the control group(1.618±0.243,F=171.907,P0.001),while Cho/Cr in lesions(1.826±0.261) was significantly increased than that in NAWM(1.503±0.216) and that in the control group(1.316±0.117,F=59.320,P 0.001).Conclusion 1H MRS can reflect the metabolic abnormalities caused by different pathological changes within the lesions and can detect the early biochemical changes in NAWM from MS patients.1H MRS has potential value in the prognosis of neurologic impairment and the evaluation of therapeutic efficacy." @default.
- W2384551314 created "2016-06-24" @default.
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- W2384551314 date "2010-01-01" @default.
- W2384551314 modified "2023-09-26" @default.
- W2384551314 title "Analysis of ~1H Magnetic Resonance Spectroscopy in Multiple Sclerosis" @default.
- W2384551314 hasPublicationYear "2010" @default.
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