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- W2384555094 abstract "Aim: To investigate the regulating effect of interleukin-2 ( IL-2) gene on the immune responseinduced by herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene in mice. Methods: Eukaryoticexpression plasmid IRES-gD which encoded HSV-1 gD gene and co-expressive nucleic vaccine plasmid ofIRES-gD-IL-2 which contained both HSV-1 gD and IL-2 gene were constructed as nucleic vaccines, and thenthey were transfected to dendritic cell(DC) by using lipofectamine, respectively, and were injected to BALB /c mice via the i.m. routes. The induced antibody titers were determined by ELISA. The DTH response in eachmouse was expressed as the difference in thickness between the left and right pinnae, the protective immuneresponses against HSV-1 challenge were evaluated. Results: Mice vaccined with IRES-gD-IL-2 had muchhigher IgG antibody titer and neutralizing antibody titer compared with the mice received IRES-gD group.Both IgG2a and IgG1 were increased in the IRES-gD-IL-2 group than those in the IRES-gD group. Moreover,the DTH response was also further increased in the IRES-gD-IL-2 group to a higher level than that in the groupwith received IRES-gD. Both of groups provided significant protection against lethal HSV-1 challenge, butthere was no difference between the two groups. Conclusion: Injection of mice with plasmid DNA co-expression of HSV-1 gD gene and IL-2 gene could enhance both cellular and humoral immune responsesefficiently, and achieve better protection against HSV-1 challenge." @default.
- W2384555094 created "2016-06-24" @default.
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- W2384555094 date "2006-01-01" @default.
- W2384555094 modified "2023-09-23" @default.
- W2384555094 title "Enhancement of DNA Vaccine Potency Against HSV-1 by Co-expression of HSV-1 gD Gene and Interleukin-2 Gene" @default.
- W2384555094 hasPublicationYear "2006" @default.
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