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- W2384562783 abstract "AIM: To investigate the role of c-jun N-terminal kinase (JNK) signaling pathway in the apoptosis of human eso-phageal cancer Eca-109 cells induced by the derivative of D-glucosamine (｛2-(3-carboxy-1-oxopropyl)amino-2-deoxy-D-Glucose｝, COPADG) and the possible mechanisms. METHODS: Eca-109 cells were cultured in vitro by using RPMI-1640 and calf serum. Eca-109 cells were pre-incubated with SP600125 for 30 min prior to exposure to COPADG at different concentrations and for different time. Changes in expression of P-JNK protein were examined by Western Blot; cell growth inhibitory rate was detected by MTT colorimetric assay; the cell morphological changes were observed by inverted phase contrast microscopy. Apoptosis rate was analyzed by using Annexin V/PI fluorescence staining together with flow cytometry. RESULTS: COPADG could significantly inhibit the proliferation of Eca-109 cells and induce their apoptosis. Western Blot showed that the protein expression of P-JNK was increased in a dose-dependent manner in Eca-109 cells after stimulated by COPADG. SP600125 remarkablely decreased the protein expression of P-JNK as well as the apoptosis rate and cell growth inhibitory rate in Eca-109 cells induced by COPADG as compared with those treated with only COPADG. CONCLUSION: JNK signaling pathway may play an important role in the apoptosis of Eca-109 cells following COPADG treatment." @default.
- W2384562783 created "2016-06-24" @default.
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- W2384562783 date "2007-01-01" @default.
- W2384562783 modified "2023-09-28" @default.
- W2384562783 title "Apoptosis in human esophageal cancer cell line Eca-109 induced by the derivative of D-glucosamine via JNK signaling pathway" @default.
- W2384562783 hasPublicationYear "2007" @default.
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