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- W2384564129 abstract "Objective To explore mechanisms of dopamine(DA) inducing GH4 cell apoptosis and glutathione(GSH)protecting GH4 cells from apoptosis induced by DA.Methods ① GH4 pituitary cells were treated with DA at 0,100,300 and 500μmol/L for 24h,then treated with DA at 500μmol/L for 0,1,3,5,12 and 24h to select the appropriate concentration and time.② Then GH4 cells were treated with raclopride(a D2 receptor antagonist,Rac)and GSH to explore the effects of Rac and GSH on apoptosis.③Apoptotic cells were counted by an inverted phase contrast microscope.Morphological appearance was observed by PI labeling,and expressions of Bcl-2 and PARP-1 were detected by Western blot.Results DA induced concentration-and time-dependent GH4 cell apoptosis.A selective D2 receptor antagonist could not block the cytotoxic effect.PI revealed that exposure to GSH(1mmol/L) for 1h prior to the DA treatment attenuated DA-induced apoptosis.Western blot showed up-regulation of Bcl-2 and down-regulation of PARP-1.Conclusion DA exerts cytotoxic effects on GH4 cells mainly through auto-oxidation in the intracellular space.A selective D2 receptor antagonist cannot block DA-induced apoptosis,while GSH can block it,which may be relevant to regulation of Bcl-2 and PARP-1." @default.
- W2384564129 created "2016-06-24" @default.
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- W2384564129 date "2011-01-01" @default.
- W2384564129 modified "2023-09-24" @default.
- W2384564129 title "Glutathione protects GH4 pituitary lactotrope tumor cells from apoptosis induced by dopamine" @default.
- W2384564129 hasPublicationYear "2011" @default.
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