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- W2384587794 abstract "Objective To explore the mechanism of myelin development abnormality induced by drinking alcohol during pregnancy. Methods In this study,oligodendrocytes were cultivated and incorporation of 3H|TdR in vitro was used as an indicator of cell proliferation The effect of alcohol and its metabolite acetaldehyde on proliferation was observed. Results The result showed that after treatment for 24 and 48 hours,cpm values in most of experimental groups were lower than those of the controls( P 0 05).With inceease in doses of alcohol and acetaldehyde,the ability on proliferation of oligodendrocytes was decreased with a dose|respone relationship.The CPM values were significantly negatively related with doses. Conclusion These results suggested that alcohol and acetaldehyde have a significant restrained action to oligodendeocytes. Alcohol and its metabolite are able to delay cell proliferation and induce cell abnormal differentiation,this is probably one of the mechanisms of myelin development abnormalities in fatal alcohol syndrome." @default.
- W2384587794 created "2016-06-24" @default.
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- W2384587794 date "2000-01-01" @default.
- W2384587794 modified "2023-09-25" @default.
- W2384587794 title "The effect on proliferation of oligodendrocytes of rats induced by alcohol and Its metabolite acetaldehyde" @default.
- W2384587794 hasPublicationYear "2000" @default.
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