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- W2384590469 abstract "Objective:To research EGFR-TKI molecular target therapy by detecting lung cancer EGFR gene mutant with high resolution melting method in different areas of China,and analyze the ratio of mutations type.Methods: To detect gene mutation of EGFR with HRM method in 253 surgical resection paraffin specimens of lung cancer and verify with gene sequencing method.Results: Mutation rate of EGFR gene was 42% in 253 cases with lung cance specimen using HRM method,while the mutation rate was 40% using sequencing method.There was no significant difference between two methods.At the same time,2 cases of T790M mutations,11 cases of multi-point mutations and 2 cases E18 new sites mutations were found using HRM method,there was no significant difference between the rates of the eastern region and the non-eastern region of patients with lung cancer EGFR mutation.The sensitivity of HRM was higher than gene sequencing method,and the specificity of HRM method was 100%.Conclusion: HRM technology has the characteristics of high sensitivity,high accuracy and high specificity.It is simpler and more cost-effective than gene sequencing method.It's necessary to specify the mutations types and to use for clinical EGFR-TKI which can provide important basis for molecular target therapy.EGFR gene mutations of the lung specimen which collect by the labs have no regional variations." @default.
- W2384590469 created "2016-06-24" @default.
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- W2384590469 date "2011-01-01" @default.
- W2384590469 modified "2023-09-23" @default.
- W2384590469 title "EGFR gene mutant tested by high resolution melting method in lung cancer" @default.
- W2384590469 hasPublicationYear "2011" @default.
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