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- W2384603010 abstract "AIM: To investigate the positive inotropic effects of human recombinant growth hormone (hr-GH) on the normal guinea-pig's heart and the influence of hr-GH on the action potential of the ventricular myocytes in isolated guinea-pig's heart. METHODS: Both methods of the langendorff's isolated heart perfusion and the glass suspension electrode were used. RESULTS: Ten minutes after the hr-GH administration for the experimental model, left ventricular systolic pressure, ±dp/dt max and left ventricular end-diastolic pressure increased obviously while heart rate decreased. The overshoot action potential duration (APD 50,APD 90), action potentialamplitude (APA) of action potential were incerased prominently. There were obvious statastic difference between the records before and after hr-GH perfusion. CONCLUSION: The hr-GH shows the positive inotropic effect on the isolated guinea-pig heart. The probable mechenism may come from the increasing of the Ca 2+ amount in myocytes." @default.
- W2384603010 created "2016-06-24" @default.
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- W2384603010 date "2002-01-01" @default.
- W2384603010 modified "2023-09-25" @default.
- W2384603010 title "Effects of human recombinant growth hormone on haemodynamics of isolated guinea-pig heart and action potential in isolated guinea-pig ventricular myocytes" @default.
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