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- W2384603183 abstract "AIM:To study the inclusion complex of prazosin hydrochloride and HP-β-CD so as to improve the performance of prazosin hydrochloride formulation.METHODS:The inclusion complex of prazosin and HP-β-CD in aqueous solution was investigated by ultraviolet spectroscopy and phase solubility method;The inclusion complexes were prepared by milling and confirmed by DTA;The content of the inclusion complex was determined by ultraviolet spectroscopy and the stability of the inclusion complex was simultaneously analyzed.RESULTS:Prazosin hydrochloride formed complex with HP-β-CD with molar ratio of 1∶1 and the binding constant of 774 M~(-1).The solubility of prazosin hydrochloride,in the presence of 5% and 10% HP-β-CD,was 16.9 and 23.6 times more than that alone.The average content of inclusion complex of three batches was 8.65%.Prazosin hydrochloride′s photo-stability was increased after complexed with HP-β-CD.CONCLUSION:HP-β-CD could improve the solubility and photo-stability of prazosin hydrochloride.It is feasible that HP-β-CD is used to improve the performance of prazosin hydrochloride formulation." @default.
- W2384603183 created "2016-06-24" @default.
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- W2384603183 date "2005-01-01" @default.
- W2384603183 modified "2023-09-25" @default.
- W2384603183 title "Inclusion Complex of Prazosin Hydrochloride/HP-β-CD" @default.
- W2384603183 hasPublicationYear "2005" @default.
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