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- W2384605647 abstract "Several epidemiological studies have shown that myeloperoxidase(MPO)-463G→A polymorphism is related with many kinds of diseases.Aims:To investigate the correlation of MPO gene polymorphism with susceptibility to gastric cancer.Methods:A total of 117 gastric cancer patients and 105 controls were enrolled.PCR-RFLP was used to determine MPO-463G→A polymorphism.Frequencies of genotype and allele were compared between the two groups.The association between MPO gene polymorphism and risk of gastric cancer was analyzed.Stratification analysis by gender, age,smoking status,Helicobacter pylori(H.pylori) infection and family history of gastric cancer was performed.Results: The frequencies of GA and AA genotype in gastric cancer group were significantly decreased than those in control group (GA:25.6%vs.37.1%,AA:3.4%vs.11.4%,P0.05),and frequency of A allele was significantly decreased(16.2%vs. 30.0%,P0.05).Compared with MPO-463GG genotype,patients with GA/AA genotype had a significantly decreased risk of gastric cancer(OR=0.43,95%CI:0.25-0.75).Stratification analysis showed that in GA/AA genotype patients with male, age equal to or less than 60 years,no smoking,H.pylori-negative or without family history of gastric cancer,the risk of gastric cancer was lower than that in patients with GG genotype.Conclusions:MPO gene polymorphism is associated with susceptibility to gastric cancer.A allele may decrease the risk of gastric cancer." @default.
- W2384605647 created "2016-06-24" @default.
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- W2384605647 date "2011-01-01" @default.
- W2384605647 modified "2023-09-24" @default.
- W2384605647 title "Correlation of Myeloperoxidase Gene Polymorphism with Susceptibility to Gastric Cancer" @default.
- W2384605647 hasPublicationYear "2011" @default.
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