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- W2384608439 abstract "Objective To compare the efficacy and safety of Tacrolimus (FK506) and Neoral CsA in conjunction with MMF (2.0 g/d) and steroid in preventing renal allograft rejection.Methods 98 cases of renal transplant recipients were randomly divided into two groups: FK506 group ( n =40), receiving tacrollimus, MMF and prednison (Pred); CsA group ( n =58), receiving CsA, MMF and Pred.Results The mean follow up time in both two groups was 12.5 months. Acute transplanted renal rejection occurred in 2 cases in FK506 group and 9 cases in CsA group respectively. The one year person/kidney survival rate was 100%/100% in FK506 group and 100%/94.8% in CsA group respectively. The dosage of Pred in FK506 group was lower than in CsA group. 12 cases in FK506 group had stopped using Pred. Hypergly cermia occurred in 7 cases in FK 506 group. Polytricosis, gingival hyperplasia and liver function disorder dominantly occurred in CsA group. Infection was found in 9 cases of FK506 group and 11 cases of CsA group respectively.Conclusion FK506 combined with MMF could decrease the occurrence of acute transplanted renal rejection and the dosage of Pred. The good adjustment of the dose of FK506 is helpful for reducing the side effects and preventing rejection." @default.
- W2384608439 created "2016-06-24" @default.
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- W2384608439 date "2000-01-01" @default.
- W2384608439 modified "2023-09-23" @default.
- W2384608439 title "The prospective randomized study on prevention of cadaveric renal allograft rejection by Tacrolimus (FK506)" @default.
- W2384608439 hasPublicationYear "2000" @default.
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