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- W2384638854 abstract "】Objective To discuss the effect of vitamin E on lung development and vascular remodeling in fetal rats with congenital diaphragmatic hernia(CDH).Methods Eighteen pregnant SD rats were randomly divided into 3 groups: control group,CDH group and intervention group.Rats in CDH group and intervention group underwent intragastric administration with nitrofen 125 mg(soluble in olive oil 2 ml).Rats in control group were given olive oil 2 ml.Rats in intervention group were given vitamin E 140 mg/kg(soluble in alcohol 2 ml) q.d for 3 days from the 11th day of pregnancy.CDH group and intervention group were given alcohol 2 ml.Results Incidence of teratogenesis caused by diaphragmatic hernia in intervention group was less than that in CDH group(46.34% vs 66.67%,P0.05).Fetal rats in control group and CDH group showed similar lung development.The lung weight/body weight ratio,axial gland alveolus count(RAC),pulmonary alveolus area proportion and pulmonary alveolus area ratio in intervention group were significantly higher than those in CDH group [(3.45±0.58) mg/g vs(2.36±0.61) mg/g,4.4±0.3 vs 2.3±0.2,(63.7±5.6)% vs(46.5±7.3)%,(45±6)% vs(27±6.7)%,P 0.01].The alveolar septum area ratio in intervention group was significantly lower than that in CDH group [(45±6.8)% vs(63±8.3)%,P 0.01].The mean media thickness percentage of pre-acinar pulmonary arteries and that of intra-acinar pulmonary arteries of fetal rats in intervention group were significantly lower than those in CDH group [(22.1±2.2)% vs(24.3±4.0)%,(17.6±2.8)% vs(21.5±2.9)%,P 0.01].The proportion of non-muscle arteries in IAPA per unit of visual field in intervention group was significantly higher than that in CDH group [(79.4±3.2)% vs(71.6±3.3)%,P 0.01].Conclusions Prenatal treatment with vitamin E can decrease the incidence of CDH,which may improve the lung development and inhibit the vascular remodeling in lung." @default.
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- W2384638854 title "Effect of vitamin E on lung development and vascular remodeling in fetal rats with congenital diaphragmatic hernia" @default.
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