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- W2384642013 abstract "Objective To explore the effects of TIMP1 in proliferation of colon carcinoma cells.Methods The pcDNA3.1-TIMP1-k plasmids and interfere plasmid were constructed and the human colon carcinoma cells(HCT-8) were transfected by them.After 48-72 h,the transcriptional level and protein level were detected by the method of real time PCR and western blot,while the growth of the HCT-8 cells was also validated by MTT.Results The pcDNA3.1-TIMP1-k plasmids and interfere plasmid were constructed successfully,while the TIMP1 gene expression was enhanced by TIMP1 over-expression plasmid and degraded by TIMP1 interfere RNA plasmid.For the four days,there was no significant difference(P0.05) in MTT.At the fifth day,there was significant difference(P0.05),yet at the sixth and seventh days,there was significant difference(P0.01).The results showed that the transcriptional and protein level were reduced by the TIMP1 interfere RNA plasmid,yet the transcriptional and protein level were elevated by the TIMP1 over-expression plasmid.While it was demonstrated that the low-expression of TIMP1 could inhibit the growth of the HCT-8 cells and the over-expression of TIMP1 could improve the growth of cells from the growth curve picture.Conclusion Up-regulated expression of TIMP1 can promote the proliferation of HCT-8 cells." @default.
- W2384642013 created "2016-06-24" @default.
- W2384642013 creator A5052856299 @default.
- W2384642013 date "2012-01-01" @default.
- W2384642013 modified "2023-09-24" @default.
- W2384642013 title "Effect of TIMP1 Gene in Proliferation of Human Colon Carcinoma Cells" @default.
- W2384642013 hasPublicationYear "2012" @default.
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