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- W2384651607 abstract "Objective To study the signal transduction pathway through which resveratrol pretreatment protects myocardial ischemia-reperfusion induced injury.Methods A cell model of ischemia-reperfusion injury was established.Cell viability was detected by trypan blue transmission method and methyl thiazolyl tetrazolium colorimetry.Lactate dehydrogenase activity in the cell culture fluid was detected.Results The cardiocyte survival rate was(35.7±7.4)% in ischemia-reperfusion group,(87.8±4.9)% in Res pretreated group was significantly different from the ischemia-reperfusion group.After being differently pretreated with N(G)-nitro-L-arginine methyl ester,methylene blue,D-sphingosine,glibenclamide,then pretreated with Res,the cardiocyte survival rate was(38.3±7.1)%,(46.3±9.7)%,(76.2±6.6)% and(72.2±5.4)% while that in N(G)-nitro-L-arginine methyl ester and MB group significantly decreased compared with Res group(P0.05),but without significant difference compared with ischemia-reperfusion injury group.After pretreatment with N(G)-nitro-L-arginine methyl ester and S-nitroso-N-acetylpenicillamine,then with Res,the cardiocyte survival rate was(86.4±4.2)%,similar to ischemia-reperfusion injury group(P0.05).The result of lactate dehydrogenase activity was the opposite.Conclusion The inhibitory effect on necrosis is cGMP-dependent and activation of protein kinase C and opening of(K+ ATP) channels are important downstream events." @default.
- W2384651607 created "2016-06-24" @default.
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- W2384651607 date "2010-01-01" @default.
- W2384651607 modified "2023-09-26" @default.
- W2384651607 title "The Study on Signal Transduction Pathway of Resvaratrol Pretreatment Effect" @default.
- W2384651607 hasPublicationYear "2010" @default.
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