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- W2384652952 abstract "Objective To study the effect of thrombolysis of inta-arterial infusion of different concentrations of urokinase(UK) in dogs. Methods 25 healthy crossbreeding dogs were divided into five groups, with five dogs in each group. Every dog was injected with self-thrombus from carotis interna artery to embolize its distal part or branchers. Treatment with different concentrations of UK was initiated 2 hours after setting up the model of cerebral embolism by carotis interna artery. The dose of each group was: A(control group), 0.9% physiological sodium chloride solution; B,1 200U/ml UK; C,6 000U/mlUK; D, 12 000U/mlUK; E, 60 000U/mlUK. Angiography and CT scannings were performed before and after thrombolysis. Pathologic examination was performed 24 hours after embolism. Results The rate of recanalization of groups A,B were 0 but 100% for groups C,D and E, Judged by angiographies after thrombolysis, group C,D and E had significantly better reperfusion compared with group A,B(P0.0001)。 Among groups C,D and E there were no significant differences but with a large bleeding in four dogs of group E after recanalization by CT scanning. Conclusions Intra-arterial thrombolysis is an effective method to treat the superacute cerebral embolism but with a range of safe and effective concentration of UK, 6 000 U/ml～12 000 U/ml, reaching high rate of thombolyes, and low rate of hemorrage." @default.
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- W2384652952 date "2004-01-01" @default.
- W2384652952 modified "2023-09-27" @default.
- W2384652952 title "An experimental investigation on the concentration of selective infusion of urokinase in superacute cerebral embolism in dog" @default.
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