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- W2384658032 abstract "AIM: To examine the alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment and its mechanism. METHODS: Acute myocardial ischemia was induced by occluding the LAD of ischemic and ECP groups. The tissue renin activity and angiotensin(AngⅡ) level in ischemic myocardium and aorta were measured. The expression of angiotensinogen and renin mRNA were detected by RT-PCR. RESULTS: Renin activity, AngⅡ level in ischemic myocardium and AngⅡ level in aorta of ECP group were lower than those of MI group. Except for renin in ischemic myocardium, angiotensinogen mRNA and renin in ischemic myocardium and angiotensinogen mRNA in aorta of ECP group were reduced to normal level. CONCLUSION: The inhibitory effect of ECP on cardiovascular renin activity and angiotensinogen gene expression could be one of the mechanisms by which ECP protects ischemic myocardium." @default.
- W2384658032 created "2016-06-24" @default.
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- W2384658032 date "2002-01-01" @default.
- W2384658032 modified "2023-09-23" @default.
- W2384658032 title "Alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment" @default.
- W2384658032 hasPublicationYear "2002" @default.
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