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- W2384658967 abstract "Objective To investigate the effect of desflurane on neuromuscular blockade of rocuronium Methods Thirty adult patients ,scheduled for selective surgery under general anesthesia, were randomly allocated to receiving intravenous propofol 4mg·mg -1 (group I,n=10),inhalation of 1MAC(6%) desflurane lasting 15 min (group Ⅱ,n=10) or 45 min(group Ⅲ,n=10) to maintain anesthesia,respectively Rocuronium 0 6 mg·kg -1 was given intravenously in group I following stable anesthesia , in group Ⅱ or group Ⅲ with the stable end tidal concentration of desflurane at 1MAC for 15 min or 45 min,respectively The onset time and degree of neuromuscular blockade were monitored with train of four(TOF) technique.Results The onset times of T 1 and TOF in group Ⅲ(1 3 and 0 8 min) were shorter than in group I(2 2 and 1 5 min)(P0 05); The clinical muscular relaxation times(the times of T 1 recovery to 25% of baseline) in group Ⅲ were longer than in group I(group I,Ⅱ and Ⅲ were 29 6,31 7 and 37 8 min, respectively)(P0 05); The times of T 1 recovery to 75% and 90% of baseline and the times of TOF ratio recovery to 0 75 in group Ⅱ and Ⅲ were longer than in group I(P0 05).Conclusions Desflurane can enhance the neuromuscular blockade effect of rocuronium ,the more degree,the longer the inhalation time, through shortening the onset time, and prolonging the action time and the restoration time." @default.
- W2384658967 created "2016-06-24" @default.
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- W2384658967 date "2000-01-01" @default.
- W2384658967 modified "2023-09-23" @default.
- W2384658967 title "Effect of desflurane on neuromuscular blockade of rocuronium" @default.
- W2384658967 hasPublicationYear "2000" @default.
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