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- W2384659480 abstract "Objective To prepare hollow microspheres of dipyridamole and evaluate its characteristics.Methods The dipyridamole hollow microspheres were prepared by solvent diffusion-evaporation method.The appearance,mean particle size,drug loading and encapsulation efficiency were investigated as the indexes to evaluate prescription.The buoyancy and drug release in vitro of optimum preparation were investigated.Results The drug loading and encapsulation efficiency of the prepared dipyridamole microspheres were found to be 11.57%and 70.12%,respectively.More than 94%of microspheres tended to float over simulate gastric fluid for 12 h.The 12 h drug release was extended to more than 80%,with no burst effect.Conclusion The dipyridamole hollow microspheres exhibit prolonged drug release and excellent floatability." @default.
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- W2384659480 date "2012-01-01" @default.
- W2384659480 modified "2023-09-23" @default.
- W2384659480 title "Preparation and evaluation of dipyridamole hollow microspheres" @default.
- W2384659480 hasPublicationYear "2012" @default.
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