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- W2384661804 abstract "To investigate the effect of rapamycin(Rapa) upon the expression of DC-SIGN on the surface of dendritic cells(DCs) and the genetic expression of the intracellular transcription factorthe PU.1 as well as the function of DCs.DCs derived from human peripheral blood mononuclear cells were cultured,and then treated with different concentrations of Rapa combined with PU.1-specific siRNA transfection.Flow cytometry and Western blotting were used to detect the expression of DC-SIGN on the surface of DC,while the cell transmigration test was used to detect the DC transmigrating ability,and the T lymphocyte proliferation was tested by means of mixed lymphocyte reaction(MLR).The experimental results showed that Rapa could down-regulate the expression of DC-SIGN in a dose-dependent manner,especially in a dose of 10 ng/ml and also it could inhibit the genetic expression of PU.1,the transmigrating ability of DCs and to stimulate T lymphocyte proliferation.After the PU.1 gene was silenced by siRNA transfection,Rapa showed no effect on DC-SIGN expression virtually.From the results in the present study,it is evident that Rapa appears to show the down-regulating effect upon DC migration and the ability to stimulate T cell proliferation through its action to inhibit DC-SIGN expression and this effect may be associated with the influence on the PU.1 gene transcription pathway." @default.
- W2384661804 created "2016-06-24" @default.
- W2384661804 creator A5056606879 @default.
- W2384661804 date "2011-01-01" @default.
- W2384661804 modified "2023-09-23" @default.
- W2384661804 title "Effect of rapamycin upon the expression of DC-SIGN on dendritic cells and the biological functions through the intracellular transcription factor PU.1" @default.
- W2384661804 hasPublicationYear "2011" @default.
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