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- W2384663526 abstract "Raddeanin A,a triterpenoid saponin,was isolated from Anemone raddeana Regel and identified by solvent extraction and recrystallization.The effect of Raddeanin A on cell proliferation,apoptosis and cell cycle progression of human non-small cell lung cancer (NSCLC) H460 cancer cells and its mechanisms in this aspect were studied in this paper.The results demonstrated that Raddeanin A significantly suppressed proliferation of H460 cancer cells in a dose-and timedependent manner which was associated with induced apoptosis and cell cycle G2-M arrest.Furthermore,Raddeanin A could inhibit Akt activation,down-regulate the expression of Bcl-2 protein,and activate the cleavage of PARP,leading to marked inhibitory effect of H460 cells.These findings suggest that Raddeanin A may be a potential usefulness for preventing and treating NSCLC." @default.
- W2384663526 created "2016-06-24" @default.
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- W2384663526 date "2010-01-01" @default.
- W2384663526 modified "2023-09-25" @default.
- W2384663526 title "Inhibitory Effect of Raddeanin A in Human Non-small Cell Lung Cancer H460 Cells" @default.
- W2384663526 hasPublicationYear "2010" @default.
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