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- W2384663990 abstract "Objective To evaluate the association of genetic polymorphism of HLA-DQ and HLA-DR-DQ linkage with Rheumatiod arthritis in Chinese Han population.Methods Odds ratios(OR) of HLA-DQ and HLA-DR alleles distributions in RA patients against healthy controls were analyzed.All the relevant studies were identified.The Meta-analysis was applied for investigating heterogeneity among individual studies and summarizing across studies.Results Four studies enroll 348 RA patients and 162 controls.HLA-DQA1*0301(OR=1.820,P0.01)and DQB1*0401(OR=4.807,P0.01) are associated with RA in Chinese Han population.DR4-DQA1*0301(OR=8.437,P0.05) and DR4-DQB1*0401(OR=3.215,P0.01) show their linkage in these patients.However,HLA-DQA1*0102(OR=0.352,P0.05)、DQB1*0602(OR=0.404,P0.01) and DQB1*0604(OR=0,P=0.05) play a protection role in RA in the same population.Conclusions HLA-DQA1*0301,DQB1*0401 and DR4-DQA1*0301 are susceptible,while HLA-DQA1*0102,DQB1*0602 and DQB1*0604 are protective to RA in Chinese Han population.DR4-DQA1*0301 and DR4-DQB1*0401 show their linkage in RA in the same population." @default.
- W2384663990 created "2016-06-24" @default.
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- W2384663990 date "2008-01-01" @default.
- W2384663990 modified "2023-09-25" @default.
- W2384663990 title "Meta-analysis of the association of HLA-DQ polymorphism and HLA-DR-DQ linkage with RA in Chinese Han population" @default.
- W2384663990 hasPublicationYear "2008" @default.
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