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- W2384665812 abstract "Objective To explore the association between polymorphisms of vitamin D receptor(VDR) gene and positive yield of acid-fast bacilli in sputum.Methods Case-control study was conducted in the(Chinese) Tibetan population.VDR Fok1 and Taq1 polymorphisms were compared among 45 patients with pulmonary tuberculosis(TB) with positive yield of acid-fast bacilli and 95 patients with negative yields by PCR-RFLP technique.Associations of VDR polymorphisms with the sputum mycobacterial culture and auramine stain were analyzed.Results The genotype frequencies of VDR-FF,VDR-Ff,VDR-ff were 36%,40%,24% in those with positive yield and 59%,33%,8% in those with negative yield,respectively.A significant increase of VDR genotype ff(mutant homozygotes) was revealed in those with positive yield when compared to those with negative yield(P0.01,OR 3.836;95% confidence interval,1.372,10.719).The genotype frequencies of VDR-TT,VDR-Tt were 96%,4% in positive yield group and 94%,6% in negative yield group,respectively.No significant difference in these genotype frequencies was observed between positive and negative subjects(P0.05).(Conclusion) The VDR-ff genotype might be associated with the pulmonary tuberculosis with positive bacterial yield in Chinese Tibetan population." @default.
- W2384665812 created "2016-06-24" @default.
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- W2384665812 date "2006-01-01" @default.
- W2384665812 modified "2023-09-27" @default.
- W2384665812 title "The relevance of vitamin D receptor gene polymorphisms to bacteriological yeilds in Chinese Tibetan patients with pulmonary tuberculosis" @default.
- W2384665812 hasPublicationYear "2006" @default.
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