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- W2384666291 abstract "Objective To investigate the effects of the fluconazole resistance and fluconazole susceptible candida albicans strains in recurrent vulvovaginal candidiasis(RVVC)on the Shapes and the Surface Molecules of the Human Peripheral Blood Monocyte-Derived dendritic cells(DCs).Methods Candida albicans in RVVC were separated and were judged by the CHROMagar Monilia colouration nutritive medium and the germ-tube-formming tests,and then were judged the fluconazole-resistance or fluconazole-usceptible strains by MIC tests.The dendritic cells were obtained by culture in vitro.Then after they were stimulated by the different doses of candida albicans including the fluconazole-esistance and fluconazole-usceptible strains of experimental groups and the ATCC10231 strains of control groups,we observed the shapes of the cells by the inverted microscope and analyzed the expressions of CD80 and CD86 by FACS.Results There were 67(62.04%) fluconazole-usceptible strains and 41(37.96%) fluconazole-esistance strains of 108 candida albicans.The levels of CD80 and CD86 expressions of the control groups were much higher than those in the same dose of experimental groups(P0.05).While the expressive levels of CD80 and CD86 of fluconazole-usceptible strains in experimental groups 1 were much higher than that of fluconazole-esistance strains in experimental groups 2(P0.05).Furthermore the levels correlated to the doses of candida albicans directly(P0.05).But there were no changes of the shapes of the cells in the two groups.Conclusion In the definite doses,candida albicans can enhance the expressions of CD80 and CD86,and then enhance the maturation of the dendritic cells.The ATCC10231 strains play best,while the fluconazole-usceptible strains play better than the fluconazole-resistance strains in this point." @default.
- W2384666291 created "2016-06-24" @default.
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- W2384666291 date "2012-01-01" @default.
- W2384666291 modified "2023-09-23" @default.
- W2384666291 title "Research on the Effects of the Fluconazole resistance and Fluconazole susceptible Candida Albicans Strains in RVVC on the Shapes and the Surface Molecules of the Human Peripheral Blood Monocyte-Derived DC_s" @default.
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