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- W2384668601 abstract "OBJECTIVE:To investigate the relationship between the genetic polymorphisms of CYP2C19 and susceptibility of anti-tuberculosis drug-induced hepatotoxicity(ATDIH) in the tuberculosis patients. METHODS:With retrospective case-control study,genetic polymorphisms of CYP2C19 were analyzed using PCR-RFLP in 106 cases of ATDIH group and 103 case without ATDIH of control group. The relationship of genetic polymorphisms with ATDIH was analyzed. RESULTS:There was no statistical significance in frequency of CYP2C19*2 or CYP2C19*3 genotype between ATDIH group and control group(P0.05). The genotypes that CYP2C19*2 combined with CYP2C19*3 were divided into three types according to metabolism rate of their double gene phenotype:rapid type,intermediate type and slow type. Logistic regression analysis demonstrated that ATDIH risk with slow metabolizer was 2.657 times of rapid metabolizer(95% CI=1.089-6.482). CONCLUSIONS:CYP2C19*2 and CYP2C19*3 genotypes might have association with the risk of ATDIH. The incidence of ATDIH in slow metabolizer is higher than that in rapid metabolizer." @default.
- W2384668601 created "2016-06-24" @default.
- W2384668601 creator A5048794978 @default.
- W2384668601 date "2014-01-01" @default.
- W2384668601 modified "2023-09-25" @default.
- W2384668601 title "Relationship between Genetic Polymorphism of CYP2C19 and Anti-tuberculosis Drug-induced Hepatotoxicity" @default.
- W2384668601 hasPublicationYear "2014" @default.
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