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- W2384674265 abstract "Objective To observe the effect of panax notoginseng saponins on expression of TNFSF13B in myocardial tissue of mice with autoimmune myocarditis(AMC) .Methods A total of 72 inbred five-week-old male BALB/C mice were randomly divided into three groups:control group(group C) ,autoimmune myocarditis group(group A) and panax notoginseng saponins group(group P) .Group A and group P were immunized with porcine heart myosin(100μg) in an equal content of CFA and a total volume of 0.2 ml,while group C was injected with PBS in an equal content of CFA.Mice in group P were subcutaneously injected with panax notoginseng saponins(40mg/kg) in inguinal groove for 5 days;while mice in groups C and A were treated with physiological saline.Eight mice of each group were sacrificed at d14,d21 and d30.The ultrastructure changes of myocardial tissue were observed with electron microscopy.The expression of TNFSF13B in myocardial tissue was detected by immunohistochemistry(IHC) .Results Electron microscopy showed pathological injury in myocardium of group P as compared with group A.The IHC demonstrated that TNFSF13B protein expression in group P was significantly lower than that in group A.Conclusion The expression of TNFSF13B is increased in AMC,while panax notoginseng saponins have a protective effect in AMC by down-regulation of the expression of TNFSF13B." @default.
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- W2384674265 date "2008-01-01" @default.
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- W2384674265 title "The expression of TNFSF13B in autoimmune myocarditis of mice and interfering effect of panax notoginseng saponin" @default.
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