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- W2384677516 abstract "Purpose:To investigate the effects of two weeks hypoxia treatment and hypoxia training on GLUT4 expression in mouse skeletal muscle and explore whether AMPK was involved in regulation of muscle GLUT4 expression induced by hypoxia treatment and hypoxia training.Methods:Expressions of GLUT4 mRNA and protein as well as the content of glycogen in quadriceps femoris muscle from control, hypoxia treatment and hypoxia training groups of AMPKα2 over-expression (OE), AMPKα2 knockout (KO), and corresponding wild-type (WT) mice was measured.Mice of hypoxia treatment groups were living in rooms with enriched nitrogen, simulating an altitude of 4,000 meter, in normobaric hypoxia (O2 12.3%) for two weeks.Hypoxia training groups were also living in this room but had an additional 60 min treadmill running training in normobaric hypoxia at the speed of 12m/min every day.Results:1)The content of GLUT4 mRNA and protein both increased significantly after two weeks hypoxia treatment as well as two weeks hypoxia training.2)The expression of muscle GLUT4 protein in AMPKα2-OE mice was significant higher than that in WT mice after two weeks hypoxia training.3)The expression of GLUT4 and the content of muscle glycogen in α2-KO mice,which were same with those in WT mice after two weeks hypoxia training,were significantly lower than that in WT mice after two weeks hypoxia treatment.Conclusion:1)The effectiveness of the hypoxia treatment and hypoxia training on expression of GLUT4 was validated in the present study.2)The AMPKα2-OE was involved in up-regulation of muscle GLUT4 expression induced by hypoxia training.3)The present study demonstrated that the cellular mechanism underlying the up-regulation of GLUT4 expression by hypoxia treatment and hypoxia training must be at least partly different,while hypoxia treatment induced GLUT4 expression in mouse skeletal muscle through a mechanism that was partially mediated by AMPKα2,pathways other than AMPKα2 were important in mediating the hypoxia training-induced GLUT4 expression." @default.
- W2384677516 created "2016-06-24" @default.
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- W2384677516 date "2010-01-01" @default.
- W2384677516 modified "2023-09-27" @default.
- W2384677516 title "Effects of Hypoxia/Hypoxia Training on GLUT4 Expression and Glycogen Storage in Skeletal Muscle of AMPKα2-WT/KO/OE Mice" @default.
- W2384677516 hasPublicationYear "2010" @default.
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