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- W2384679303 abstract "Objective: To find the effect of different CYP3A4*1G genotypes on pharmacokinetics of bisoprolol's in healthy volunteers. Methods: CYP3A4*1G genotypes were determined by real-time PCR. 24 healthy people were divided into three different genotype groups of CC, CT and TT(n=8) in the research. All of them were administered with bisoprolol fumarate tablet as a single dosage of 5mg. Plasma concentrations of bisoprolol were measured by HPLC. Results: The main pharmacokinetic parameters of CC, CT and TT were as follows: t1/2(7.79±1.57)、(7.49±0.77)、(7.88±1.21)h,Cmax(37.23±4.00)、(38.33±8.94)、(39.51±6.55)?g/L and AUC0-32(386.42±91.49),(375.53±84.51),(406.24±87.24)μg·h/L. There was no significant differences among the three genotypes by T test(P0.05). Conclusion: The individual differences of bisoprolol's pharmacokinetics has no relationship with CYP3A4*1G genotypes." @default.
- W2384679303 created "2016-06-24" @default.
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- W2384679303 date "2014-01-01" @default.
- W2384679303 modified "2023-09-26" @default.
- W2384679303 title "A Research of Relationship between CYP3A4*1G Genetic Polymorphisms and Bisoprolol's Pharmacokinetic" @default.
- W2384679303 hasPublicationYear "2014" @default.
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