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- W2384681930 abstract "Objective To investigate the effects of β2-AR overexpression on IL-18 content secreted by cardiomyocytes of heart failure rats. Methods The rats model of chronic heart failure was established by partially banding abdominal aorta and the cardiomyocyte was isolated with collagenase II, then the cardiomyocyte was transfected with Ad5-ADRbeta2-EGFP for 48 h to observe the changes of β2-AR protein expression in Western Blot and IL-18 content in ELISA. The experiment was divided into six groups: HF group, HF+EGFP group, HF+β2 group,sham group, sham+EGFP group and sham+β2 group. Results Compared with the sham-operated group, left ventricular diastolic dimension(LVEDD),left ventricular systolic dimension(LVESD) were all increased(P0.05), ejection fraction(EF)and fractional shortening(FS) were decreased(P0.05) in HF group.Compared with HF group and HF+EGFP group, the expression of β2-AR protein of cardiomyocytes was increased in HF+β2 group(P0.05). Compared with sham group, IL-18 content secreted by cardiomyocytes in HF group was significantly increased(P0.05). Compared with HF group and HF+EGFP group, IL-18 content in HF+β2 group were both increased(P0.05). Conclusion The content of IL-18 is increased in the cardiomyocytes of heart failure rats. The overexpressed β2-AR protein can decrease the IL-18 content secreted by cardiomyocytes of heart failure rats." @default.
- W2384681930 created "2016-06-24" @default.
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- W2384681930 date "2013-01-01" @default.
- W2384681930 modified "2023-09-24" @default.
- W2384681930 title "Effects of adenovirus mediated β2-AR overexpression on IL-18 level secreted by cardiomyocytes of heart failure rats" @default.
- W2384681930 hasPublicationYear "2013" @default.
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