Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384685152> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2384685152 abstract "OBJECTIVE To prepare a new intravenous tetrandrine emulsion and evaluate its properties.METHODS First,the formulation and preparation method of intravenous tetrandrine emulsion were optimized by orthogonal-design.Then the quality and stability were investigated.Furthermore,the pharmacokinetics and tissue distribution as well as the irritation to auricular veins were studied in rabbits.RESULTS The optimized formulation of intravenous tetrandrine emulsion was composed of 100 mg·mL-1 MCT,50 mg·mL-1 LCT,30 mg·mL-1 phospholipid,5 mg·mL-1 oleic acid and water phase.The pH value was adjusted to 7-7.5.The emulsion was homogenized 2-4 times at 105 kPa,then sterilized for 15 min at 121 ℃.This intravenous emulsion was stable at low temperatures.The pharmacokinetics and tissue distribution of intravenous tetrandrine emulsion were similar with those of tetrandrine injection.However,the emulsion had slighter irritation.CONCLUSION The formulation and preparation method of intravenous tetrandrine emulsion optimized in the current study are reliable.The emulsion can decrease the irritation of tetrandrine." @default.
- W2384685152 created "2016-06-24" @default.
- W2384685152 creator A5056534110 @default.
- W2384685152 date "2011-01-01" @default.
- W2384685152 modified "2023-09-26" @default.
- W2384685152 title "Preparation and Evaluation of Intravenous Tetrandrine Emulsion" @default.
- W2384685152 hasPublicationYear "2011" @default.
- W2384685152 type Work @default.
- W2384685152 sameAs 2384685152 @default.
- W2384685152 citedByCount "0" @default.
- W2384685152 crossrefType "journal-article" @default.
- W2384685152 hasAuthorship W2384685152A5056534110 @default.
- W2384685152 hasConcept C112705442 @default.
- W2384685152 hasConcept C185592680 @default.
- W2384685152 hasConcept C203014093 @default.
- W2384685152 hasConcept C2777063393 @default.
- W2384685152 hasConcept C2778123984 @default.
- W2384685152 hasConcept C2779934757 @default.
- W2384685152 hasConcept C43617362 @default.
- W2384685152 hasConcept C55493867 @default.
- W2384685152 hasConcept C71924100 @default.
- W2384685152 hasConcept C98274493 @default.
- W2384685152 hasConceptScore W2384685152C112705442 @default.
- W2384685152 hasConceptScore W2384685152C185592680 @default.
- W2384685152 hasConceptScore W2384685152C203014093 @default.
- W2384685152 hasConceptScore W2384685152C2777063393 @default.
- W2384685152 hasConceptScore W2384685152C2778123984 @default.
- W2384685152 hasConceptScore W2384685152C2779934757 @default.
- W2384685152 hasConceptScore W2384685152C43617362 @default.
- W2384685152 hasConceptScore W2384685152C55493867 @default.
- W2384685152 hasConceptScore W2384685152C71924100 @default.
- W2384685152 hasConceptScore W2384685152C98274493 @default.
- W2384685152 hasLocation W23846851521 @default.
- W2384685152 hasOpenAccess W2384685152 @default.
- W2384685152 hasPrimaryLocation W23846851521 @default.
- W2384685152 hasRelatedWork W146873958 @default.
- W2384685152 hasRelatedWork W1988348418 @default.
- W2384685152 hasRelatedWork W2005720785 @default.
- W2384685152 hasRelatedWork W2034380061 @default.
- W2384685152 hasRelatedWork W2036134384 @default.
- W2384685152 hasRelatedWork W2037722733 @default.
- W2384685152 hasRelatedWork W2071872569 @default.
- W2384685152 hasRelatedWork W2083015453 @default.
- W2384685152 hasRelatedWork W2171211821 @default.
- W2384685152 hasRelatedWork W2328054847 @default.
- W2384685152 hasRelatedWork W2363018464 @default.
- W2384685152 hasRelatedWork W2376302675 @default.
- W2384685152 hasRelatedWork W2378687715 @default.
- W2384685152 hasRelatedWork W2379351561 @default.
- W2384685152 hasRelatedWork W2384706651 @default.
- W2384685152 hasRelatedWork W2466044159 @default.
- W2384685152 hasRelatedWork W2891148677 @default.
- W2384685152 hasRelatedWork W3019112590 @default.
- W2384685152 hasRelatedWork W788504857 @default.
- W2384685152 hasRelatedWork W2882270545 @default.
- W2384685152 isParatext "false" @default.
- W2384685152 isRetracted "false" @default.
- W2384685152 magId "2384685152" @default.
- W2384685152 workType "article" @default.