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- W2384685283 abstract "Aim To investigate the effects of Curcumin on Heme oxygenase isozymes in SH-SY5Y cells and explore a new mechanism of Curcumin in neuroprotection. Methods The human SH-SY5Y cells were cultured in vitro and treated with Curcumin at 0,1.25,5.0,20 μmol·L-1 for 24 h,or with Curcumin at 5.0 μmol·L-1 for 0,12,24,and 48 h. The active oxygen was detected by fluorescent probe DCFH-DA and fluorospectro-photometer. RT-PCR was used to detect the expression of HO-1 and HO-2 mRNA. Western blot was performed to detect the levels of HO-1 and HO-2 protein.Results The results showed that Curcumin could inhibit the levels of active oxygen(P0.05). HO-1 levels were increased in a dose-and time-dependent manner (P0.05) after Curcumin treatment.Whereas,the levels of HO-2 mRNA and protein were gradually decreased(P0.05). A negative correlation was found between HO-1 and HO-2. Conclusion Curcumin has the capability of anti-oxidative stress and regulated HO-1 and HO-2 bilaterally,which may be a new mechanism of the function of Curcumin on anti-oxidative stress." @default.
- W2384685283 created "2016-06-24" @default.
- W2384685283 creator A5083429698 @default.
- W2384685283 date "2010-01-01" @default.
- W2384685283 modified "2023-09-23" @default.
- W2384685283 title "The effect of two ways regulation of Curcumin on expression of HO isozymes in SH-SY5Y cells" @default.
- W2384685283 hasPublicationYear "2010" @default.
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