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- W2384694689 abstract "Objective To study the relationship between the plasma level of interferon-gamma(IFN-γ) and the polymorphism of IFN-γ single nucleotide(SNP) with the enterovirus71(EV71) infection. Methods Reverse transcription polymerase chain reaction(RT-PCR) was used to detect the specific primers of EV71 in the faeces of patients with hand,foot and mouth disease(HFMD).The plasma levels of IFN-γ were detected by enzyme-linked immunosorbent assay. Results EV71 was positive in 43 specimens from 78 children with HFMD.Compared with that of the normal children,the plasma levels of IFN-γ of the patients were significantly increased(t=6.477,P0.01).In EV71 group AA genotype was more common than in the normal group(χ2=6.149,P0.05).In EV71 group,the IFN-γ A allele was more common than in normal immune group(χ2=7.486,P0.05).In EV71 group,there was no significant difference in the distribution of frequency of IFN-γ gene+874 site between encephalitis children and non-encephalitis children(P0.05),but A allele frequency was higher in encephalitis(χ2=6.211,P0.05). Conclusion Plasma level of IFN-γ expression and the polymorphism of IFN-γ +874A/T single nucleotide may co-relate with the enterovirus71 infection,and,with the susceptibility of individual to encephalitis." @default.
- W2384694689 created "2016-06-24" @default.
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- W2384694689 date "2010-01-01" @default.
- W2384694689 modified "2023-09-24" @default.
- W2384694689 title "RELATIONSHIP BETWEEN THE PLASMA LEVEL OF IFN-γ AND THE POLYMORPHISM OF IFN-γ SINGLE NUCLEOTIDE WITH ENTEROVIRUS 71 INFECTION" @default.
- W2384694689 hasPublicationYear "2010" @default.
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