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- W2384700450 abstract "Objective To investigate the effect of recombinant human bone morphogenetic protein-2 sustained release hydrogel microspheres (reBMP2-dex-HM) on the proliferation and differentiation of osteoblasts.Methods The secondary culture osteoblasts were divided into three groups according to the different ingredients being added into the DMEM culture medium:rhBMP-2 group (A),dex-HM group (B) and rhBMP2-dex-HM group (C).The proliferation of the cultured osteoblasts was measured by using cell counting method,MTT method and flow cytometry.The contents of bone BGP secreted by osteoblasts were also measured by RIA method.Results The in vitro cellular study showed no significant difference in the cell number and cell viability on the second day after plate culture,but 2 days later the cell number and cell viability in group A were significantly increased as compared with those in other groups (P0.05).Six to 8 days after plate culture,the cell number and cell viability in group C were increased as compared with other two groups (P0.01).After 14 days,the cell number in groups A,B and C was ( 22.97± 0.23),( 13.89± 0.57) and ( 32.46± 0.67)×104 cells/ml,with the difference being significant among them (P0.01).The flow cytometry revealed that the G_2/M+S percentage in group C were the highest 4-8 days after plate culture (P 0.05).Among the three groups,the content of BGP in group C was the highest.Conclusion The rhBMP2 -dex-HM can promote the proliferation and differentiation of osteoblasts through a long period of controlled release of rhBMP-2.Hydrogel microspheres may be an ideal controlled release carrier for growth factors." @default.
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- W2384700450 date "2005-02-08" @default.
- W2384700450 modified "2023-09-25" @default.
- W2384700450 title "Effect of recombinant human bone morphogenetic protein-2 sustained release microspheres on the proliferation and differentiation of osteoblasts" @default.
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